PhD in Bioinformatics
Technion - Israel Institute of Technology
Dissertation Topic: Mapping by Admixture Linkage Disequilibrium - New Criteria and Algorithms
Sivan completed his Ph.D. as an Azrieli Fellow at the Computer Science Department of the Technion - Israel Institute of Technology, on the subject of Mapping by Admixture Linkage Disequilibrium, under the supervision of Prof. Geiger. He later went on to post-doctoral research at the Computer Science Department in Stanford.
Currently, Sivan is a Research Scientist at Prof. Batzoglou's lab in Stanford. He is also the Head of Science and Technology at a medical diagnostics company called Silicon Valley Bio-Systems. The company's core product is a set of software algorithms that process DNA sequence data to determine likely causes for patients' hereditary diseases.
By applying a probabilistic approach to problems in human genetics, his research aims to develop algorithms for unveiling the hidden relations between ancestry and genetic disorders. The methods developed offer new ways to predict inherited risks of diseases, with immediate implications on preventive and therapeutic solutions.
Sivan's main research interests include Genetic Mapping and Machine-Learning, but he also enjoys studying Distributed Systems (especially Peer-to-Peer Systems), Computer Architecture and more.
A personal perspective:
"During my PhD studies, I had the privilege to be an Azrieli Fellow and participate in this unique program. Both the academic and social activities enriched my PhD experience. The Azrieli program not only provided a bridge to peers in sister universities, but also widened my collaborations, enabling me to reach well beyond my field of research".
• S. Bercovici, D. Geiger. 2011. Admixture Aberration Analysis: Application to mapping in admixed population using pooled DNA. Journal of Computational Biology. 18(3): 237-249.
• S. Bercovici, C. Meek, Y. Wexler, D. Geiger. 2010. Estimating genomewide IBD-sharing from SNP data via an efficient hidden Markov model of LD with application to gene mapping. Bioinformatics 26 (12): Pages: i175-i182.
• S. Bercovici, I. Sharon, T. Shlomi, R. Pinter. 2010. Pathway-Based Functional Analysis of Metagenomes. Journal of Computational Biology 18(3): 495-505.
• D. M. Behar, S. Rosset, S. Tzur, S. Selig, G. Yudkovsky, S. Bercovici, J. B. Kopp, C. A. Winkler, G. W. Nelson, W. G. Wasser, and Karl Skorecki. 2010. African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans. Human Molecular Genetics 1;19 (9):1816-27.
• Liran I Shlush, Sivan Bercovici, Walter G Wasser, Guennady Yudkovsky, Alan Templeton, Dan Geiger and Karl Skorecki. 2010. Admixture Mapping of End Stage Kidney Disease Genetic Susceptibility Using Expected Mutual Information Ancestry Informative Markers. BMC Medical Genomics 3(1):47
• S. Bercovici, D. Geiger. 2009. Inferring Ancestries Efficiently in Admixed Populations with Linkage Disequilibrium. Journal of Computational Biology, 16 (8): 1141-50.
• S. Bercovici, D. Geiger, L. Shlush, K. Skorecki, A. Templeton. 2008. Panel Construction for Mapping in Admixed Populations via Expected Mutual Information. Genome Research Journal 18: 661-667.
• J. Nousbeck, R. Spiegel, A. Ishida-Yamamoto, M. Indelman, A. Shani-Adir, N. Adir, E. Lipkin, S. Bercovici, D. Geiger, M. A. van Steensel, P. M. Steijlen, R. Bergman, A. Bindereif, M. Choder, S. Shalev, E. Sprecher. 2008. Alopecia, Neurological defects and Endocrinopathy (ANE) syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis. American Journal of Human Genetics 82: 1114-1121.
• Shraer, S. Bercovici, G. Chockler, I. Keidar, R. Melamed, Y. Tock, and R. Vitenberg. Local Building Blocks for a Scalable Pub/Sub Infrastructure. Presented at the 2nd Workshop on Locality Preserving Distributed Computing Methods (LOCALITY '07) co-located with PODC'07; 2007 August 16; Portland, Oregon, USA.
• S. Bercovici, Y. Frishman, I. Keidar, and Ayellet Tal. Decentralized Electronic-Mail. In proceedings International Workshop on Dynamic Distributed Systems (IWDDS) in conjunction with the 26th International Conference on Distributed Computing Systems (ICDCS); 2006 July 4-7; P. 14; Lisbon, Portugal.