PhD in Molecular Genetics
Weizmann Institute of Science
Dissertation Topic: Genetic circuit design based on robustness considerations.
Omer is a graduate of the Weizmann Institute of Science in the field of Molecular Genetics. With a background in Physics, and an affinity to Biology, Omer took an interdisciplinary approach to his research, applying mathematical modeling to complex genetic systems. By combining theoretical analysis with critical experimentation, he tackled a central topic in developmental biology, seeking factors that enable robust and precise cellular differentiation through organism development.
Currently Omer is a CTO at NRGENE, an Israeli biotech start-up. NRGENE develops cutting-edge genomic analysis tools for the seed industry, aiming to identify the genetic basis for the diverse performance of individual plants (http://www.nrgene.com/).
In the future, Omer plans to continue to develop cutting-edge algorithms to enable advance usage of genomics information to support agricultural / medical challenges.
A Personal Perspective:
In Omer's words: "As an Azrieli Fellow, I was privileged to receive very generous financial support during my PhD studies. But more importantly, the comprehensive program which included meetings, special events and volunteering activity, surrounded by informal, warm support by the program team members and the Azrieli family, has strengthened me with values of generosity and social responsibility".
• Barad O, Mann M, Chapnik E, Shenoy A, Blelloch R, Barkai N and Hornstein E. 2012. Efficiency and specificity in microRNA biogenesis. Nature Structural & Molecular Biology (19):650–652 doi:10.1038/nsmb.2293
• Afek Y, Alon N, Barad O, Hornstein E, Barkai N, Bar-Joseph Z. 2011. A biological solution to a fundamental distributed computing problem. Science. Jan 14; 331 (6014): 183-5. PMID: 21233379.
• Mann M, Barad O, Agami R, Geiger B, Hornstein E. 2010. miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate. Proc Natl Acad Sci U S A. Sep 7; 107 (36): 15804-9. PMID: 20720163
• Barad O, Rosin D, Hornstein E, Barkai N. 2010. Error minimization in lateral inhibition circuits. Sci Signal. Jul 6; 3 (129): ra51. PMID: 20606215
• Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE. 2006. The colorectal microRNAome. Proc Natl Acad Sci U S A. Mar 7; 103 (10): 3687-92. PMID: 16505370
• Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z. 2005. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet. Jul; 37 (7): 766-70. PMID: 15965474
• Barad O, Meiri E, Avniel A, Aharonov R, Barzilai A, Bentwich I, Einav U, Gilad S, Hurban P, Karov Y, Lobenhofer EK, Sharon E, Shiboleth YM, Shtutman M, Bentwich Z, Einat P. 2004 MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues. Genome Res. Dec; 14 (12):2486-94. PMID: 15574827
• Golan-Mashiach M, Dazard JE, Gerecht-Nir S, Amariglio N, Fisher T, Jacob-Hirsch J, Bielorai B, Osenberg S, Barad O, Getz G, Toren A, Rechavi G, Itskovitz-Eldor J, Domany E, Givol D. 2005. Design principle of gene expression used by human stem cells: implication for pluripotency. FASEB J. Jan; 19 (1):147-9. PMID: 15498892