Dr. Ziv Shulman
Ziv is a new faculty member at the Weizmann Institute of Science in the Department of Immunology, returning to Israel from a postdoctoral position at Rockefeller University in New York City. His group at the Weizmann explores the cellular and molecular components that underlie successful immune response. His studies focus on generation of protecting antibodies in response to vaccination or pathogen invasion, a process known as antibody affinity maturation. In this process improved antibodies are formed by insertion of mutations into the antibody encoding genes and selection of the best emerging variants. By using a intravital imaging methods and mice bearing fluorescent reporters, Shulman’s group visualize and quantify the interactional dynamics, molecular interactions and signaling events that control efficient antibody formation and selection during inflammation in lymph nodes and intestinal tissues. Ziv’s ultimate aim is to translate his basic science knowledge about the antibody immune response for developing new generations of therapeutic human antibodies for treating cancer patients.