Jonathan Jeffet

Jonathan Jeffet is a PhD student in the School of Physics and Astronomy at Tel Aviv University. His research deals with developing optical methods for single-molecule genomics. Jonathan wishes to enable simultaneous mapping of genetic (DNA sequence), and epigenetic (various chemical and structural DNA modifications that do not alter the sequence) information. The impact of these genetic and epigenetic features on cell activity and human diseases is at the heart of biological research and personalized medicine. Through a combination of nano-fabrication to trap and stretch single DNA molecules, and the construction of a novel fluorescence microscopy scheme, Jonathan hopes to simultaneously visualize and analyze all the information encoded on the human genome. Using this method, he aims to establish a complete and comprehensive view of the genomic characteristics of individual chromosomes, thus opening new avenues for basic genomic research and affordable personalized clinical diagnosis, prognosis and treatment.