Michal Levo

Michal Levo is working on her PhD in the field of computational biology at the Weizmann Institute of Science.
In her research, she seeks to understand how the DNA sequence encodes the binding of regulatory proteins and how these, then dictate gene expression.
Using systematic large scale experiments and computational analysis, she hopes to gain a quantitative, mechanistic understanding of transcription regulation,
providing new insights into the dynamics underlying genetically based diseases and paving the way for directed design of gene expression. 
Michal intends to start her postdoc studies at Princeton University in the summer of 2015. 

•    Michal Levo*, Einat Zalckvar*, Eilon Sharon, Ana Carolina Dantas Machado, Yael Kalma, Maya Lotam-Pompan, Adina Weinberger, Zohar Yakhini, Remo Rohs, Eran Segal.
Unraveling determinants of transcription factor binding outside the core binding site. Genome Research, (March 2015)
* Equal contribution

•    Michal Levo and Eran Segal. In pursuit of design principles of regulatory sequences
Nature Reviews Genetics, (July 2014) 15(7):453-68

•    Maya Dadiani, David van Dijk Barak Segal, Yair Field, Gail Ben-Artzi Gil, Tali Raveh-Sadka, Michal Levo, Irene Kaplow, Adina Weinberger, Eran Segal. Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise. 
Genome Research, (June 2013) 23(6):966-76

•    Eilon Sharon*, Yael Kalma*, Ayala Sharp, Tali Raveh-Sadka, Michal Levo, Danny Zeevi, Leeat Keren, Zohar Yakhini, Adina Weinberger, Eran Segal. Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoter. Nature Biotechnology, (May 2012) 20;30(6):521-30

•    Tali Raveh-Sadka*, Michal Levo*, Uri Shabi, Boaz Shany, Leeat Keren, Maya Lotan-Pompan, Danny Zeevi, Eilon Sharon, Adina Weinberger, Eran Segal. Manipulating nucleosome disfavoring sequences allows fine-tune regulation of gene expression in yeast. 
Nature Genetics, (May 2012) 27;44(7):743-50
* Equal contribution
o    Chosen for Faculty of 1000 Biology:
o    Highlighted in News and Views, (2012) Nature Genetics , 27;44(7):735-6

•    Danny Zeevi*, Eilon Sharon*, Maya Lotan-Pompan, Yaniv Lubling, Zohar Shipony, Tali Raveh-Sadka, Leeat Keren, Michal Levo, Adina Weinberger and Eran Segal. Compensation for differences in gene copy number among yeast ribosomal proteins is encoded within their promoters. 
Genome Research, (Dec. 2011) 21(12):2114-28

•    Tali Raveh-Sadka*, Michal Levo*, Eran Segal. 
Incorporating Nucleosomes into Thermodynamic Models of Transcription Regulation Genome Research, (Aug. 2009) 19:1480-1496 
* Equal contribution

•    Ophir Shalem, Orna Dahan, Michal Levo, Maria Rodriguez Martinez, Itay Furman, Eran Segal & Yitzhak Pilpel. Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation.
Molecular Systems Biology, (Oct. 2008) 4:223
o    Chosen for Faculty of 1000 Biology: