Elad Noor

PhD in Biochemistry
Weizmann Institute of Science
Dissertation Topic: Studying Evolutionary Constraints through Design and Analysis of Metabolic Pathways

Currently, Elad is postdoctoral fellow at ETH Zürich, at Prof. Uwe Sauer's lab. I am studying a phenomenon called substrate channeling, where two different enzymes pass an intermediate compound between them.
I have been an Azrieli fellow during my PhD at the Weizmann Institute, where I studied the natural constraints that apply to metabolic pathways and how to engineer new ones. Being an Azrieli fellow was a great opportunity to meet excellent academics from diverse fields and have a chance to get a glimpse of what their research is about. 

  • W. Liebermeister*, E. Noor*, A. Flamholz, D. Davidi, J. Bernhardt, R. Milo (2014) A visual account of protein investment in cellular functions, PNAS
  • E. Noor*, A. Bar-Even*, A. Flamholz, E. Reznik, W. Liebermeister, R. Milo (2014) Pathway thermodynamics uncovers kinetic obstacles in central metabolism, PLOS Comput. Biol.
  • N. Tepper*, E. Noor*, D. Amador-Noguez, H. S. Haraldsdóttir, R. Milo, J. Rabinowitz, W. Liebermeister, T. Shlomi (2013) Steady-State Metabolite Concentrations Reflect a Balance between Maximizing Enzyme Efficiency and Minimizing Total Metabolite Load, PloS one
  • E. Noor, A. Flamholz, W. Liebermeister, A. Bar-Even, R. Milo (2013) A Note on the Kinetics of Enzyme Action: a Decomposition that Highlights Thermodynamic Effects, FEBS Letters
  • E. Noor*, H. Haraldsdottir*, R. Milo, R. M.T. Fleming (2013) Consistent Estimation of Gibbs Energy using Component Contributions, PLOS Comput. Biol.
  • A. Levin-Karp, U. Barenholz, T. Bareia, M. Dayagi, L. Zelcbuch, N. Antonovsky, E. Noor, R. Milo (2013) Quantifying translational coupling in E. coli synthetic operons using RBS modulation and fluorescent reporters, ACS Synthetic Biology
  • R. Hecht, E. Noor, G. Dobry, Y. Zigel, A. Bar-Hillel, N. Tishby (2013) Effective Model Representation by Information Bottleneck Principle, IEEE Trans. Audio Speech Lang. Proc.
  • A. Flamholz*, E. Noor*, A. Bar-Even, W. Liebermeister, R. Milo (2013) Glycolytic Strategy as a Tradeoff Between Energy Yield and Protein Cost, PNAS
  • L. Zelcbuch*, N. Antonovsky*, A. Bar-Even, A. Levin-Karp, U. Barenholz, M. Dayagi, W. Liebermeister, A. Flamholz, E. Noor, S. Amram, A. Brandis, T. Bareia, I. Yofe, H. Jubran, R. Milo (2013) Spanning high-dimensional expression space using ribosome-binding site combinatorics, Nucleic Acids Res.
  • A. Bar-Even, E. Noor, A. Flamholz, R. Milo (2012) Design and analysis of metabolic pathways supporting formatotrophic growth for electricity-dependent cultivation of microbes, Biochim Biophys Acta - Bioenergetics
  • E. Noor, N. Lewis, R. Milo (2012) A proof for loop-law constraints in stoichiometric metabolic networks, BMC Systems Biology
  • E. Noor, R. Milo (2012) Efficiency in Evolutionary Trade-Offs, Science [perspective]
  • E. Noor*, A. Bar-Even*, A. Flamholz, Y. Lubling, D. Davidi, R. Milo (2012) An integrated open framework for thermodynamics of reactions that combines accuracy and coverage. Bioinformatics
  • A. Bar-Even, A. Flamholz, E. Noor, R. Milo (2012) Thermodynamic constraints shape the structure of carbon fixation pathways, Biochim Biophys Acta
  • A. Bar-Even, A. Flamholz, E. Noor, R. Milo (2012) Rethinking glycolysis: on the biochemical logic of metabolic pathways, Nature Chem. Biol. [review article]
  • A. Bar-Even, E. Noor, R. Milo (2011) A survey of carbon fixation pathways through a quantitative lens, J. Exp. Bot. [review article]
  • A. Flamholz, E. Noor, A. Bar-Even, R. Milo (2011) eQuilibrator--the biochemical thermodynamics calculator, Nucleic Acids Res.
  • A. Bar-Even, E. Noor, A. Flamholz, J.M. Buescher, R. Milo (2011) Hydrophobicity and Charge Shape Cellular Metabolite Concentrations, PLOS Comput. Biol.
  • A. Bar-Even*, E. Noor*, Y. Savir, W. Liebermeister, D. Davidi, D. Tawfik, R. Milo (2011) The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters, Biochemistry
  • E. Noor, E. Eden, R. Milo, U. Alon (2010) Central Metabolism as a Minimal Biochemical Walk between Precursors for Biomass and Energy, Molecular Cell
  • A. Bar-Even, E. Noor, N. Lewis, R. Milo (2010) Design and Analysis of Synthetic Carbon Fixation Pathways, PNAS
  • Y. Savir, E. Noor, R. Milo, T. Tlusty (2009) Cross-species analysis traces adaptation of Rubisco towards optimality in a low dimensional landscape, PNAS
  • R. Hecht, E. Noor, N. Tishby (2009) Gaussian Information Bottleneck for Speaker Recognition, Interspeech
  • N. Kashtan, E. Noor, U. Alon (2007) Varying Environments can speed up Evolution, PNAS25. E. Noor and H. Aronowitz (2006) Efficient Language Identification using Anchor Models and Support Vector Machines, IEEE Odyssey  (* equal contribution)
Elad joined Engineers Without Borders (an NGO that focuses on engineering projects in third-world countries) and was part of a group of students that planned, designed and built a rainwater collection system at a public school in Tanzania. Many of the children in the village of Minjingu were suffering from a condition called bone fluorosis which was cased by the high concentrations of fluoride in the drinking water. The system was installed in September 2014 and is now providing clean and healthy water to the children in the school (link to the facebook page). He started working on this project in 2012, and was one of the first volunteers that joined the team. "It was a very fulfilling experience and a great pleasure to work with other motivated people who sincerely want to use their expertise to help others."