PhD in Computational Biology
Weizmann Institute of Science
Research Topic: Computational approaches for prediction of molecular and global phenotypes from genotype.
Ohad is a computational biologist, researching the broad question of "Genotype to Phenotype", and more specifically, how can genetic changes such as nucleotide polymorphisms between human individuals affect their gene expression profile or susceptibility to a certain disease. Currently, Ohad is finalizing his PhD at the lab of Prof. Eran Segal in Weizmann institute of Science.
After completing his PhD, Ohad intends to continue research as a postdoctoral fellow in the department of Genome Sciences, UW in Seattle, under the supervision of Prof. Elhanan Borenstein. The research will deal with development of computational tools to help understand the relation between the human gut microbiome and the host health.
A Personal Perspective:
"As an Azrieli Fellow, I had a wonderful experience, both in terms of interacting with people from different disciplines and in the feeling of being part of a big family. I continue to recommend other students I meet to apply and try to be a part of this very special family".
• Manor O, Segal E. 2013. Robust Prediction of Expression Differences among Human Individuals Using Only Genotype Information. PLoS Genet 9 (3): e1003396. doi:10.1371/journal.pgen.1003396
• Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F, Shi Y, Segal E, Chang HY. 2010. Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes. Science. Aug 6; 329(5992):689-93
• Avraham R, Sas-Chen A, Manor O, Steinfeld I, Shalgi R, Tarcic G, Bossel N, Zeisel A, Amit I, Zwang Y, Enerly E, Russnes HG, Biagioni F, Mottolese M, Strano S, Blandino G, Børresen-Dale AL, Pilpel Y, Yakhini Z, Segal E, Yarden Y. 2010. EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors. Science Signaling. 3(124): p. ra43
• Novershtern N, Itzhaki Z, Manor O, Friedman N, Kaminski N. 2008. A functional and regulatory map of asthma. Am J Respiratory Cell Mol Biol. March; 38(3): 324–336.